Monitoring the Site-Specific Solid-State NMR Data in Oligopeptides
نویسندگان
چکیده
منابع مشابه
Site-Specific Identification of an Aβ Fibril–Heparin Interaction Site by Using Solid-State NMR Spectroscopy**
At the surface of Aβ(1-40) amyloid fibrils that have a threefold molecular symmetry (green in the left picture) a site of interaction of the glycosaminoglycan analogue heparin (blue) was identified. The binding site consists of residues at the N terminus and the turn regions defining the apices of the triangular geometry. Heparin has a lower affinity for Aβ(1-40) fibrils having twofold molecula...
متن کاملHydrogen-bonding Effect on 15n Nmr Chemical Shifts of the Glycine Residue of Oligopeptides in the Solid State as Studied by High-resolution Solid-state Nmr Spectroscopy
19 HIgh-resolutIOn I5N NMR spectra of a vanety ofsohd ohgopeptIdes (X-Gly-Gly) contammg glycme resIdues have been measured, of whIch the crystal structures had already been determmed by X-ray dIffractIOn The expenmental '5N chemIcal shIfts of the glycme reSIdues were plotted agamst the N"'O hydrogen bond length and the N-H bond length m the :-C=O··· H-N; type hydrogen bond form, respectively It...
متن کاملSolid-State NMR Spectroscopy
A number of arylamides have been synthesized and found to exhibit potent antimicrobial activities against a broad spectrum of Gram-positive and Gram-negative bacteria while exhibiting low toxicity toward eukaryotic cells. These facially amphiphilic foldamers have a relatively rigid intramolecular hydrogen-bonded arylamide as a framework, which places trifluormethyl versus positively charged ami...
متن کاملSolid State NMR Probe Design
The majority of solids NMR experiments today are driven by biological applications in rigid macromolecules, where even the most advanced liquids methods are limited by the spectral resolution they can achieve. Obtaining detailed structural information from NMR of solid samples is often more technically demanding than for liquids because of the absence of molecular tumbling in solids to average ...
متن کاملSolid-State Diffusion and NMR
Diffusion in solids, which requires the presence of crystal defects or disorder, has both microscopic and macroscopic aspects. Nuclear magnetic resonance techniques provide access to microscopic diffusion parameters like atomic jump rates and activation energies as well as to the tracer diffusion coefficient for macroscopic transport. Microscopic NMR methods include spin-lattice relaxation spec...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21082700